What is Cell cargo?

What is Cell cargo?

Cargos (e.g. secretory vesicles) carried by plus-end directed kinesins are translocated along microtubules toward the cortex. Upon reaching the dense cortical actin meshwork the cargo is transferred to myosin Va for delivery to the cell membrane (Figure 1).

What do cargo proteins do?

Cargo Proteins Facilitate the Formation of Transport Vesicles in the Cytoplasm to Vacuole Targeting Pathway.

What do cargo proteins bind to?

Soluble (luminal) cargo proteins may require cargo receptors to link with the cytosolic COPII coat. These transmembrane ER proteins contain ER export motifs in their cytoplasmic tail and can transiently bind the soluble cargo in the ER lumen.

What is cargo motor protein?

The kinesin superfamily of proteins represents a large class of motor proteins that carry cargo along microtubules. Conventional kinesins move along microtubule filaments in a manner that resembles human walking.

How do motor proteins move cargo?

Motor proteins, such as myosins and kinesins, move along cytoskeletal filaments via a force-dependent mechanism that is driven by the hydrolysis of ATP molecules (reviewed in [1]).

What is in Golgi apparatus?

The Golgi apparatus consists of a stack of flattened cisternae and associated vesicles. Proteins and lipids from the ER enter the Golgi apparatus at its cis face and exit at its trans face.

What transports proteins in a cell?

The Endoplasmic Reticulum or ER is an extensive system of internal membranes that move proteins and other substances through the cell. The part of the ER with attached ribosomes is called the rough ER. The rough ER helps transport proteins that are made by the attached ribosomes.

What are transport vesicles?

Definition: Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, or to destinations within or outside the cell.